Hypoxia activates the cyclin D1 promoter via the Jak2/STAT5b pathway in breast cancer cells

@article{Joung2005HypoxiaAT,
  title={Hypoxia activates the cyclin D1 promoter via the Jak2/STAT5b pathway in breast cancer cells},
  author={Youn Hee Joung and Eun Joung Lim and M Y Lee and Jong-Hwan Park and Sang-Kyu Ye and Eui U. Park and Seong Yoon Kim and Zheng Zhang and Kwang Jeon Lee and Dong Ki Park and Taekyu Park and Won Kook Moon and Young Mok Yang},
  journal={Experimental & Molecular Medicine},
  year={2005},
  volume={37},
  pages={353-364}
}
Hypoxia, a common consequence of solid tumor growth in breast cancer or other cancers, serves to propagate a cascade of molecular pathways which include angiogenesis, glycolysis, and various cellcycle control proteins. As we have shown previously, hypoxia activates STAT5 (signal transducer and activator of transcription 5) and increases its binding activity to the GAS element in mammary epithelial cells. In this study we attempted to elucidate the mechanism by which cyclin D1 is regulated by… CONTINUE READING

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