Hypoxia activates Akt and induces phosphorylation of GSK-3 in PC12 cells.

@article{BeitnerJohnson2001HypoxiaAA,
  title={Hypoxia activates Akt and induces phosphorylation of GSK-3 in PC12 cells.},
  author={Dana Beitner-Johnson and Randall T. Rust and T. C. Hsieh and David E. Millhorn},
  journal={Cellular signalling},
  year={2001},
  volume={13 1},
  pages={23-7}
}
Akt is a serine/threonine kinase that has been shown to play a central role in promoting cell survival and opposing apoptosis. We evaluated the effect of hypoxia on Akt in rat pheochromocytoma (PC12) cells. PC12 cells were exposed to varying levels of hypoxia, including 21%, 15%, 10%, 5%, and 1% O(2). Hypoxia dramatically increased phosphorylation of Akt (Ser(473)). This effect peaked after 6 h exposure to hypoxia, but persisted strongly for up to 24 h. Phosphorylation of Akt was paralleled… CONTINUE READING

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