Hypoxia-activated ligand HAL-1/13 is lupus autoantigen Ku80 and mediates lymphoid cell adhesion in vitro.

@article{Lynch2001HypoxiaactivatedLH,
  title={Hypoxia-activated ligand HAL-1/13 is lupus autoantigen Ku80 and mediates lymphoid cell adhesion in vitro.},
  author={Eric Lynch and Robert B. Moreland and Irene Ginis and Susan P. Perrine and Douglas V Faller},
  journal={American journal of physiology. Cell physiology},
  year={2001},
  volume={280 4},
  pages={C897-911}
}
Hypoxia is known to induce extravasation of lymphocytes and leukocytes during ischemic injury and increase the metastatic potential of malignant lymphoid cells. We have recently identified a new adhesion molecule, hypoxia-activated ligand-1/13 (HAL-1/13), that mediates the hypoxia-induced increases in lymphocyte and neutrophil adhesion to endothelium and hypoxia-mediated invasion of endothelial cell monolayers by tumor cells. In this report, we used expression cloning to identify this molecule… CONTINUE READING