Hypoxia-activated autophagy accelerates degradation of SQSTM1/p62

  title={Hypoxia-activated autophagy accelerates degradation of SQSTM1/p62},
  author={J-P Pursiheimo and Krista Rantanen and Pekka T. Heikkinen and Terje Johansen and Panu M. Jaakkola},
Sequestosome 1 (SQSTM1/p62) is a multifunctional protein involved in signal transduction, protein degradation and cell transformation. Hypoxia is a common feature of solid tumours that promotes cancer progression. Here, we report that p62 is downregulated in hypoxia in carcinoma cells and that the expression is rapidly restored in response to reoxygenation. The hypoxic p62 downregulation did not occur at the mRNA level and was independent of the hypoxic signal mediators hypoxia-inducible factor… CONTINUE READING


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