Hypoxia Promotes Osteogenesis but Suppresses Adipogenesis of Human Mesenchymal Stromal Cells in a Hypoxia-Inducible Factor-1 Dependent Manner

@inproceedings{Wagegg2012HypoxiaPO,
  title={Hypoxia Promotes Osteogenesis but Suppresses Adipogenesis of Human Mesenchymal Stromal Cells in a Hypoxia-Inducible Factor-1 Dependent Manner},
  author={Markus Wagegg and Timo Gaber and Ferenz Leonard Lohanatha and Martin Hahne and Cindy Strehl and Monique Fangradt and Cam Loan Tran and Kerstin Sch{\"o}nbeck and Paula Hoff and Andrea Ode and Carsten Perka and Georg N. Duda and Frank Buttgereit},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Bone fracture initiates a series of cellular and molecular events including the expression of hypoxia-inducible factor (HIF)-1. HIF-1 is known to facilitate recruitment and differentiation of multipotent human mesenchymal stromal cells (hMSC). Therefore, we analyzed the impact of hypoxia and HIF-1 on the competitive differentiation potential of hMSCs towards adipogenic and osteogenic lineages. METHODOLOGY/PRINCIPAL FINDINGS Bone marrow derived primary hMSCs cultured for 2 weeks… CONTINUE READING
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Initial immune reaction and angiogenesis in bone healing.

Journal of tissue engineering and regenerative medicine • 2014
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