Hypoxia Inducible Factor Signaling Modulates Susceptibility to Mycobacterial Infection via a Nitric Oxide Dependent Mechanism

Abstract

Tuberculosis is a current major world-health problem, exacerbated by the causative pathogen, Mycobacterium tuberculosis (Mtb), becoming increasingly resistant to conventional antibiotic treatment. Mtb is able to counteract the bactericidal mechanisms of leukocytes to survive intracellularly and develop a niche permissive for proliferation and dissemination… (More)
DOI: 10.1371/journal.ppat.1003789

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Cite this paper

@inproceedings{Elks2013HypoxiaIF, title={Hypoxia Inducible Factor Signaling Modulates Susceptibility to Mycobacterial Infection via a Nitric Oxide Dependent Mechanism}, author={Philip M. Elks and Sabrina Brizee and Michiel van der Vaart and Sarah R. Walmsley and Fredericus J. M. van Eeden and Stephen A. Renshaw and Annemarie H. Meijer}, booktitle={PLoS pathogens}, year={2013} }