Hypoxia Inducible Factor-1alpha and Vascular Endothelial Growth Factor in Biopsies of Small Cell Lung Carcinoma

@article{Ioannou2009HypoxiaIF,
  title={Hypoxia Inducible Factor-1alpha and Vascular Endothelial Growth Factor in Biopsies of Small Cell Lung Carcinoma},
  author={Maria Ioannou and Rodula Papamichali and Evangelos Kouvaras and Ilias Mylonis and Dimitra P Vageli and T. Kerenidou and Sotirios Barbanis and Alexandros Daponte and George Simos and Konstantinos I. Gourgoulianis and George K. Koukoulis},
  journal={Lung},
  year={2009},
  volume={187},
  pages={321-329}
}
Neoangiogenesis has been documented in small cell lung carcinoma (SCLC). In addition, antiangiogenic therapies are being tested in clinical trials that involve SCLC. However, study of the underlying mechanisms has been performed almost exclusively in cell lines. In the current study, we immunostained 30 biopsy samples of SCLC with antibodies to hypoxia inducible factor-1alpha (HIF-1alpha), vascular endothelial growth factor (VEGF), vascular endothelial growth factor-receptor 1 (VEGF-R1/flt-1… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 24 CITATIONS

Apatinib for chemotherapy-refractory extensive-stage SCLC: a retrospective study

  • Cancer Chemotherapy and Pharmacology
  • 2019
VIEW 1 EXCERPT
CITES BACKGROUND

Role of the HIF-1 signaling pathway in chronic obstructive pulmonary disease

  • Experimental and therapeutic medicine
  • 2018
VIEW 2 EXCERPTS
CITES RESULTS

References

Publications referenced by this paper.
SHOWING 1-10 OF 46 REFERENCES

MgcRacGAP interacts with HIF-1alpha and regulates its transcriptional activity.

  • Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
  • 2007

The role of hypoxia-inducible factors in cancer

  • Cellular and Molecular Life Sciences
  • 2007
VIEW 1 EXCERPT

Expression of hypoxia-inducible factor-1 alpha and its prognostic significance in small-sized adenocarcinomas of the lung.

  • European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • 2006
VIEW 1 EXCERPT

Similar Papers