Hypoxia-Inducible Factor-1 (HIF-1)

@article{Ke2006HypoxiaInducibleF,
  title={Hypoxia-Inducible Factor-1 (HIF-1)},
  author={Qingdong Ke and Max Costa},
  journal={Molecular Pharmacology},
  year={2006},
  volume={70},
  pages={1469 - 1480}
}
Adaptation to low oxygen tension (hypoxia) in cells and tissues leads to the transcriptional induction of a series of genes that participate in angiogenesis, iron metabolism, glucose metabolism, and cell proliferation/survival. The primary factor mediating this response is the hypoxia-inducible factor-1 (HIF-1), an oxygen-sensitive transcriptional activator. HIF-1 consists of a constitutively expressed subunit HIF-1β and an oxygen-regulated subunit HIF-1α (or its paralogs HIF-2α and HIF-3… 

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