Hypoxia-Inducible Factor (HIF)-1 Regulatory Pathway and its Potential for Therapeutic Intervention in Malignancy and Ischemia

@article{Ziello2007HypoxiaInducibleF,
  title={Hypoxia-Inducible Factor (HIF)-1 Regulatory Pathway and its Potential for Therapeutic Intervention in Malignancy and Ischemia},
  author={Jennifer E. Ziello and Ion S. Jovin and Yan Huang},
  journal={The Yale Journal of Biology and Medicine},
  year={2007},
  volume={80},
  pages={51 - 60}
}
Hypoxia-Inducible Factor (HIF)-1 is a dimeric protein complex that plays an integral role in the body's response to low oxygen concentrations, or hypoxia. HIF-1 is among the primary genes involved in the homeostatic process, which can increase vascularization in hypoxic areas such as localized ischemia and tumors. It is a transcription factor for dozens of target genes; HIF-1 is also essential for immunological responses and is a crucial physiological regulator of homeostasis, vascularization… CONTINUE READING

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HIF-1α-deficiency results in dysregulated EPO signaling and iron homeostasis in mouse development

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