Hypoxia Inducible Factor (HIF)-1 Coordinates Induction of Toll-Like Receptors TLR2 and TLR6 during Hypoxia

@article{Kuhlicke2007HypoxiaIF,
  title={Hypoxia Inducible Factor (HIF)-1 Coordinates Induction of Toll-Like Receptors TLR2 and TLR6 during Hypoxia},
  author={Johannes Kuhlicke and Julia Stefanie Frick and Julio C{\'e}sar Morote-Garcia and Peter Rosenberger and Holger K. Eltzschig},
  journal={PLoS ONE},
  year={2007},
  volume={2},
  pages={783 - 801}
}
BACKGROUND During acute infection and inflammation, dramatic shifts in tissue metabolism are typical, thereby resulting in profound tissue hypoxia. Therefore, we pursued the hypothesis, that tissue hypoxia may influence innate immune responses by transcriptional modulation of Toll-like receptor (TLRs) expression and function. METHODOLOGY/PRINCIPAL FINDINGS We gained first insight from transcriptional profiling of murine dendritic cells exposed to hypoxia (2% oxygen for 24 h). While transcript… CONTINUE READING
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