Hypoxia Induces EMT in Low and Highly Aggressive Pancreatic Tumor Cells but Only Cells with Cancer Stem Cell Characteristics Acquire Pronounced Migratory Potential

@inproceedings{Salnikov2012HypoxiaIE,
  title={Hypoxia Induces EMT in Low and Highly Aggressive Pancreatic Tumor Cells but Only Cells with Cancer Stem Cell Characteristics Acquire Pronounced Migratory Potential},
  author={Alexei V. Salnikov and Li Liu and Mitja Platen and Jury Gladkich and Olga Salnikova and Eduard Ryschich and Juergen Mattern and Gerhard Moldenhauer and Jens Werner and Peter Schemmer and Markus W. B{\"u}chler and Ingrid Herr},
  booktitle={PloS one},
  year={2012}
}
Tumor hypoxia induces epithelial-mesenchymal transition (EMT), which induces invasion and metastasis, and is linked to cancer stem cells (CSCs). Whether EMT generates CSCs de novo, enhances migration of existing CSCs or both is unclear. We examined patient tissue of pancreatic ductal adenocarcinoma (PDA) along with carcinomas of breast, lung, kidney, prostate and ovary. For in vitro studies, five established PDA cell lines classified as less (CSC(low)) and highly aggressive CSC-like cells (CSC… CONTINUE READING

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