Hypoxia Induces Alteration of Bone Morphogenetic Protein Receptor Signaling in Pulmonary Artery Endothelial Cell

Abstract

Reduced expression of bone morphogenetic protein receptors (BMPR) has been implicated in the pathogenesis of pulmonary hypertension (PH), but changes in the intracellular signaling pathway of BMPR have not been fully understood. We hypothesized that BMPR signaling in pulmonary endothelial cells is altered during the development of PH, such as hypoxia… (More)
DOI: 10.1203/pdr.0b013e3180332cba

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