Hypoxia-Induced Reactive Oxygen Species Cause Chromosomal Abnormalities in Endothelial Cells in the Tumor Microenvironment

@inproceedings{Kondoh2013HypoxiaInducedRO,
  title={Hypoxia-Induced Reactive Oxygen Species Cause Chromosomal Abnormalities in Endothelial Cells in the Tumor Microenvironment},
  author={Miyako Kondoh and Noritaka Ohga and Ken-ichi Akiyama and Yasuhiro Hida and Nako Maishi and Alam Mohammad Towfik and Norihisa Inoue and Masanobu Shindoh and Kyoko Hida},
  booktitle={PloS one},
  year={2013}
}
There is much evidence that hypoxia in the tumor microenvironment enhances tumor progression. In an earlier study, we reported abnormal phenotypes of tumor-associated endothelial cells such as those resistant to chemotherapy and chromosomal instability. Here we investigated the role of hypoxia in the acquisition of chromosomal abnormalities in endothelial cells. Tumor-associated endothelial cells isolated from human tumor xenografts showed chromosomal abnormalities, >30% of which were… CONTINUE READING

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