Hypoxia-Induced Neuroinflammation and Learning–Memory Impairments in Adult Zebrafish Are Suppressed by Glucosamine

@article{Lee2018HypoxiaInducedNA,
  title={Hypoxia-Induced Neuroinflammation and Learning–Memory Impairments in Adult Zebrafish Are Suppressed by Glucosamine},
  author={Yunkyoung Lee and Sujeong Lee and Ji-Won Park and Ji-Sun Hwang and Sang-Min Kim and In Kyoon Lyoo and Chang-Joong Lee and Inn-Oc Han},
  journal={Molecular Neurobiology},
  year={2018},
  volume={55},
  pages={8738-8753}
}
This study investigated changes in neuroinflammation and cognitive function in adult zebrafish exposed to acute hypoxia and protective effects of glucosamine (GlcN) against hypoxia-induced brain damage. The survival rate of zebrafish following exposure to hypoxia was improved by GlcN pretreatment. Moreover, hypoxia-induced upregulation of neuroglobin, NOS2α, glial fibrillary acidic protein, and S100β in zebrafish was suppressed by GlcN. Hypoxia stimulated cell proliferation in the telencephalic… Expand
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