Hypoxia-Induced Iron Accumulation in Oligodendrocytes Mediates Apoptosis by Eliciting Endoplasmic Reticulum Stress

@article{Rathnasamy2015HypoxiaInducedIA,
  title={Hypoxia-Induced Iron Accumulation in Oligodendrocytes Mediates Apoptosis by Eliciting Endoplasmic Reticulum Stress},
  author={Gurugirijha Rathnasamy and Madhuvika Murugan and Eng-Ang Ling and Charanjit Kaur},
  journal={Molecular Neurobiology},
  year={2015},
  volume={53},
  pages={4713-4727}
}
This study was aimed at evaluating the role of increased iron accumulation in oligodendrocytes and its role in their apoptosis in the periventricular white matter damage (PWMD) following a hypoxic injury to the neonatal brain. In response to hypoxia, in the PWM, there was increased expression of proteins involved in iron acquisition, such as iron regulatory proteins (IRP1, IRP2) and transferrin receptor in oligodendrocytes. Consistent with this, following a hypoxic exposure, there was increased… CONTINUE READING

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