Hypoxia Enhances S-Nitrosylation-Mediated NMDA Receptor Inhibition via a Thiol Oxygen Sensor Motif

@article{Takahashi2007HypoxiaES,
  title={Hypoxia Enhances S-Nitrosylation-Mediated NMDA Receptor Inhibition via a Thiol Oxygen Sensor Motif},
  author={H. Takahashi and Yeonsook Shin and Seung-Je Cho and W. Zago and Tomohiro Nakamura and Z. Gu and Yuliang Ma and Hiro Furukawa and R. Liddington and Dongxian Zhang and Gary G Tong and Huei-Sheng Vincent Chen and S. Lipton},
  journal={Neuron},
  year={2007},
  volume={53},
  pages={53-64}
}
Under ambient air conditions, NO inhibits NMDAR activity by reacting with the NR2A subunit C399 along with two additional cysteine pairs if their disulfide bonds are reduced to free thiol groups [NR1(C744,C798); NR2(C87,C320)]. Here we demonstrate that relative hypoxia enhances S-nitrosylation of NMDARs by a unique mechanism involving an "NO-reactive oxygen sensor motif" whose determinants include C744 and C798 of the NR1 subunit. Redox reactions involving these two thiol groups sensitize other… Expand
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