Hypoxia Due to Cardiac Arrest Induces a Time-Dependent Increase in Serum Amyloid β Levels in Humans

@inproceedings{Zetterberg2011HypoxiaDT,
  title={Hypoxia Due to Cardiac Arrest Induces a Time-Dependent Increase in Serum Amyloid β Levels in Humans},
  author={Henrik Zetterberg and Erik M{\"o}rtberg and Linan Song and Lei Chang and Gail K. Provuncher and Purvish P. Patel and Evan P. Ferrell and David R. Fournier and Cheuk Wai Kan and Todd G. Campbell and Ray Meyer and Andrew J. Rivnak and Brian A. Pink and Kaitlin A. Minnehan and Tomasz Piech and David M. Rissin and David C. Duffy and Sten Rubertsson and David Henry Wilson and K Blennow},
  booktitle={PloS one},
  year={2011}
}
Amyloid β (Aβ) peptides are proteolytic products from amyloid precursor protein (APP) and are thought to play a role in Alzheimer disease (AD) pathogenesis. While much is known about molecular mechanisms underlying cerebral Aβ accumulation in familial AD, less is known about the cause(s) of brain amyloidosis in sporadic disease. Animal and postmortem studies suggest that Aβ secretion can be up-regulated in response to hypoxia. We employed a new technology (Single Molecule Arrays, SiMoA) capable… CONTINUE READING

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Amyloid β ( Aβ ) peptides are proteolytic products from amyloid precursor protein ( APP ) and are thought to play a role in Alzheimer disease ( AD ) pathogenesis .
Amyloid β ( Aβ ) peptides are proteolytic products from amyloid precursor protein ( APP ) and are thought to play a role in Alzheimer disease ( AD ) pathogenesis .
Alzheimer's DiseaseAssociated with malfunction of gene productAPP protein, human
Amyloid β ( Aβ ) peptides are proteolytic products from amyloid precursor protein ( APP ) and are thought to play a role in Alzheimer disease ( AD ) pathogenesis .
Amyloid β ( Aβ ) peptides are proteolytic products from amyloid precursor protein ( APP ) and are thought to play a role in Alzheimer disease ( AD ) pathogenesis .
Amyloid β ( Aβ ) peptides are proteolytic products from amyloid precursor protein ( APP ) and are thought to play a role in Alzheimer disease ( AD ) pathogenesis .
Amyloid β ( Aβ ) peptides are proteolytic products from amyloid precursor protein ( APP ) and are thought to play a role in Alzheimer disease ( AD ) pathogenesis .
Amyloid β ( Aβ ) peptides are proteolytic products from amyloid precursor protein ( APP ) and are thought to play a role in Alzheimer disease ( AD ) pathogenesis .
Amyloid β ( Aβ ) peptides are proteolytic products from amyloid precursor protein ( APP ) and are thought to play a role in Alzheimer disease ( AD ) pathogenesis .
Amyloid β ( Aβ ) peptides are proteolytic products from amyloid precursor protein ( APP ) and are thought to play a role in Alzheimer disease ( AD ) pathogenesis .
Amyloid β ( Aβ ) peptides are proteolytic products from amyloid precursor protein ( APP ) and are thought to play a role in Alzheimer disease ( AD ) pathogenesis .
Amyloid β ( Aβ ) peptides are proteolytic products from amyloid precursor protein ( APP ) and are thought to play a role in Alzheimer disease ( AD ) pathogenesis .
Amyloid β ( Aβ ) peptides are proteolytic products from amyloid precursor protein ( APP ) and are thought to play a role in Alzheimer disease ( AD ) pathogenesis .
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