Hypoxia/reoxygenation: a dynamic regulator of lysyl oxidase-facilitated breast cancer migration.

@article{Postovit2008HypoxiareoxygenationAD,
  title={Hypoxia/reoxygenation: a dynamic regulator of lysyl oxidase-facilitated breast cancer migration.},
  author={Lynne-Marie Postovit and Daniel Abbott and Stacey L Payne and William W. Wheaton and Naira V. Margaryan and Richard J. Sullivan and Matthias K. Jansen and Katalin Csisz{\'a}r and Mary J. C. Hendrix and Dawn A. Kirschmann},
  journal={Journal of cellular biochemistry},
  year={2008},
  volume={103 5},
  pages={
          1369-78
        }
}
Fluctuating oxygen levels characterize the microenvironment of many cancers and tumor hypoxia is associated with increased invasion and metastatic potential concomitant with a poor prognosis. Similarly, the expression of lysyl oxidase (LOX) in breast cancer facilitates tumor cell migration and is associated with estrogen receptor negative status and reduced patient survival. Here we demonstrate that hypoxia/reoxygenation drives poorly invasive breast cancer cells toward a more aggressive… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 40 CITATIONS

Similar Papers

Loading similar papers…