Hypoxia/oxidative stress alters the pharmacokinetics of CPU86017-RS through mitochondrial dysfunction and NADPH oxidase activation

@inproceedings{Gao2013HypoxiaoxidativeSA,
  title={Hypoxia/oxidative stress alters the pharmacokinetics of CPU86017-RS through mitochondrial dysfunction and NADPH oxidase activation},
  author={Jie Gao and Xuan-sheng Ding and Yu-mao Zhang and De-zai Dai and Mei Liu and Can Yang Zhang and Yin Dai},
  booktitle={Acta Pharmacologica Sinica},
  year={2013}
}
Aim:Hypoxia/oxidative stress can alter the pharmacokinetics (PK) of CPU86017-RS, a novel antiarrhythmic agent. The aim of this study was to investigate the mechanisms underlying the alteration of PK of CPU86017-RS by hypoxia/oxidative stress.Methods:Male SD rats exposed to normal or intermittent hypoxia (10% O2) were administered CPU86017-RS (20, 40 or 80 mg/kg, ig) for 8 consecutive days. The PK parameters of CPU86017-RS were examined on d 8. In a separate set of experiments, female SD rats… CONTINUE READING

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