Hypoxia, inflammation, and the tumor microenvironment in metastatic disease

  title={Hypoxia, inflammation, and the tumor microenvironment in metastatic disease},
  author={Elizabeth C. Finger and Amato J. Giaccia},
  journal={Cancer and Metastasis Reviews},
Metastasis, the leading cause of cancer deaths, is an intricate process involving many important tumor and stromal proteins that have yet to be fully defined. This review discusses critical components necessary for the metastatic cascade, including hypoxia, inflammation, and the tumor microenvironment. More specifically, this review focuses on tumor cell and stroma interactions, which allow cell detachment from a primary tumor, intravasation to the blood stream, and extravasation at a distant… CONTINUE READING


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The role of tumor cell-derived connective tissue growth factor (CTGF/CCN2) in pancreatic tumor growth

  • Bennewith, L K.
  • Cancer Research,
  • 2009
Highly Influential
3 Excerpts

Relation to MMP-2 activation and lymph node metastasis

  • R. Hosotani, et al. . Expression of integrin alphaVbeta3 in pancre carcinoma
  • Pancreas, 25(2), e30–e35. 290 Cancer Metastasis…
  • 2010

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