Hypoxia, hypoxia-inducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesis.

@article{Sluimer2008HypoxiaHT,
  title={Hypoxia, hypoxia-inducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesis.},
  author={Judith C. Sluimer and Jean-Marie Gasc and Job L van Wanroij and Natasja Kisters and Mathijs Groeneweg and Maarten D Sollewijn Gelpke and Jack P. M. Cleutjens and Luc H J M van den Akker and Pierre Corvol and Bradly G. Wouters and Mat J. A. P. Daemen and Ann-Pascale J. J. Bijnens},
  journal={Journal of the American College of Cardiology},
  year={2008},
  volume={51 13},
  pages={1258-65}
}
OBJECTIVES We sought to examine the presence of hypoxia in human carotid atherosclerosis and its association with hypoxia-inducible transcription factor (HIF) and intraplaque angiogenesis. BACKGROUND Atherosclerotic plaques develop intraplaque angiogenesis, which is a typical feature of hypoxic tissue and expression of HIF. METHODS To examine the presence of hypoxia in atherosclerotic plaques, the hypoxia marker pimonidazole was infused before carotid endarterectomy in 7 symptomatic… CONTINUE READING