Hypoxia, hypoxia-inducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesis.

@article{Sluimer2008HypoxiaHT,
  title={Hypoxia, hypoxia-inducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesis.},
  author={J. Sluimer and Jean-Marie Gasc and J. L. van Wanroij and N. Kisters and M. Groeneweg and Maarten D Sollewijn Gelpke and J. Cleutjens and L. H. van den Akker and P. Corvol and B. Wouters and M. Daemen and Ann-Pascale J J Bijnens},
  journal={Journal of the American College of Cardiology},
  year={2008},
  volume={51 13},
  pages={
          1258-65
        }
}
  • J. Sluimer, Jean-Marie Gasc, +9 authors Ann-Pascale J J Bijnens
  • Published 2008
  • Medicine
  • Journal of the American College of Cardiology
  • OBJECTIVES We sought to examine the presence of hypoxia in human carotid atherosclerosis and its association with hypoxia-inducible transcription factor (HIF) and intraplaque angiogenesis. BACKGROUND Atherosclerotic plaques develop intraplaque angiogenesis, which is a typical feature of hypoxic tissue and expression of HIF. METHODS To examine the presence of hypoxia in atherosclerotic plaques, the hypoxia marker pimonidazole was infused before carotid endarterectomy in 7 symptomatic… CONTINUE READING
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