Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing

Abstract

This article outlines the need for a homeostatic response to alterations in cellular oxygenation. It describes work on erythropoietin control that led to the discovery of the hypoxia-inducible transcription factor (HIF-1) and the parallel recognition that this system was responsive to a widespread oxygen-sensing mechanism. Subsequently, multiple HIF… (More)
DOI: 10.1007/s00018-009-0147-7

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