Hypoxia, Oxidative Stress and Fat

  title={Hypoxia, Oxidative Stress and Fat},
  author={Nikolaus C. Netzer and Hannes Gatterer and Martin Faulhaber and Martin Burtscher and Stephan Pramsohler and Dominik Pesta and Michael Breitenbach and Peter Eckl},
Metabolic disturbances in white adipose tissue in obese individuals contribute to the pathogenesis of insulin resistance and the development of type 2 diabetes mellitus. Impaired insulin action in adipocytes is associated with elevated lipolysis and increased free fatty acids leading to ectopic fat deposition in liver and skeletal muscle. Chronic adipose tissue hypoxia has been suggested to be part of pathomechanisms causing dysfunction of adipocytes. Hypoxia can provoke oxidative stress in… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 5 times over the past 90 days. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 15 extracted citations


Publications referenced by this paper.
Showing 1-10 of 32 references

Emerging role of adipose tissue hypoxia in obesity and insulin resistance

  • J. Ye
  • Int. J. Obes. 2009,
  • 2009
Highly Influential
3 Excerpts

Characterization of the inflammatory and metabolic profile of adipose tissue in a mouse model of chronic hypoxia

  • B. Van den Borst, A. M. Schols, +4 authors H. R. Gosker
  • J. Appl. Physiol
  • 2013
1 Excerpt

Similar Papers

Loading similar papers…