Hypoxanthine-guanine phosphoribosyl-transferase in childhood leukemia: relation with immunophenotype, in vitro drug resistance and clinical prognosis.

@article{Pieters1992HypoxanthineguaninePI,
  title={Hypoxanthine-guanine phosphoribosyl-transferase in childhood leukemia: relation with immunophenotype, in vitro drug resistance and clinical prognosis.},
  author={Rob Pieters and Dieuwke R. Huismans and Anne H. Loonen and Godefridus J. Peters and Karel H{\"a}hlen and Anna van der Does-van den Berg and Elisabeth R van Wering and Anjo J. P. Veerman},
  journal={International journal of cancer},
  year={1992},
  volume={51 2},
  pages={213-7}
}
Decreased activity of hypoxanthine-guanine phosphoribosyl-transferase (HGPRT), responsible for the conversion of 6-mercaptopurine and 6-thioguanine (6-TG) to their cytotoxic nucleotides, may cause resistance to these thiopurines in experimental leukemic systems. The clinical significance of this mechanism is as yet unclear. In 83 children with untreated acute lymphoblastic leukemia (ALL), we determined the prognostic value of HGPRT activity and the relation between HGPRT activity and resistance… CONTINUE READING