Hypotonicity induces membrane protrusions and actin remodeling via activation of small GTPases Rac and Cdc42 in Rat-1 fibroblasts.

@article{Carton2003HypotonicityIM,
  title={Hypotonicity induces membrane protrusions and actin remodeling via activation of small GTPases Rac and Cdc42 in Rat-1 fibroblasts.},
  author={Iris Carton and Diane Hermans and Jan Eggermont},
  journal={American journal of physiology. Cell physiology},
  year={2003},
  volume={285 4},
  pages={C935-44}
}
An important consequence of cell swelling is the reorganization of the F-actin cytoskeleton in different cell types. We demonstrate in this study by means of rhodamine-phalloidin labeling and fluorescence microscopy that a drastic reorganization of F-actin occurs in swollen Rat-1 fibroblasts: stress fibers disappear and F-actin patches are formed in… CONTINUE READING