Hypotonicity and ethanol modulate BK channel activity and chloride currents in GH4/C1 pituitary tumour cells.

@article{Jakab2006HypotonicityAE,
  title={Hypotonicity and ethanol modulate BK channel activity and chloride currents in GH4/C1 pituitary tumour cells.},
  author={Martin Jakab and SusanneM. Schmidt and Michael Grundbichler and Markus Paulmichl and Anton Hermann and Thomas M. Weiger and Markus Ritter},
  journal={Acta physiologica},
  year={2006},
  volume={187 1-2},
  pages={51-9}
}
AIM Description of the effects of hypotonic cell swelling and ethanol on maxi Ca2+-activated K+ channel (BK channel) activity and Cl- channel activity in GH4/C1 pituitary tumour cells. METHODS Whole cell-, cell attached- and outside-out patch clamp measurements, fluorescence (fluo-3) measurements of intracellular Ca2+ concentration, cell size video monitoring. RESULTS GH4/C1 pituitary tumour cells respond to both hypotonicity and ethanol with cell swelling which is followed by a regulatory… CONTINUE READING

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