Hypotonic stress increases efficacy of rilmakalim, but not pinacidil, to activate ATP-sensitive K(+) current in guinea pig ventricular myocytes.

Abstract

The aim of this study was to investigate the influence of hypotonic challenge on the effects of potassium channel openers (PCO), rilmakalim and pinacidil, on activation of the ATP-sensitive K(+) current. The whole cell configuration of the patch-clamp technique was applied to guinea pig ventricular myocytes exposed to isotonic and hypotonic solutions… (More)

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@article{Koci2004HypotonicSI, title={Hypotonic stress increases efficacy of rilmakalim, but not pinacidil, to activate ATP-sensitive K(+) current in guinea pig ventricular myocytes.}, author={Ivan Koci{\'c} and Yuji Hirano and Masayasu Hiraoka}, journal={Journal of pharmacological sciences}, year={2004}, volume={95 2}, pages={189-95} }