Hypotonic cisplatin treatment for carcinomatous pleuritis found at thoracotomy in patients with lung cancer. In vitro experiments and preliminary clinical results.

@article{Ichinose1993HypotonicCT,
  title={Hypotonic cisplatin treatment for carcinomatous pleuritis found at thoracotomy in patients with lung cancer. In vitro experiments and preliminary clinical results.},
  author={Yukito Ichinose and Nobuyuki Hara and Mitsunori Ohta and Hiroshi Asoh and Tokujiro Yano and Katsuhide Maeda and Kumi Yagawa},
  journal={The Journal of thoracic and cardiovascular surgery},
  year={1993},
  volume={105 6},
  pages={1041-6}
}
We have developed an intraoperative intrapleural treatment with the use of distilled water combined with cisplatin for carcinomatous pleuritis found at thoracotomy in patients with non-small-cell lung cancer. In the in vitro experiment, three different cell lines were used as a model of malignant pleural effusion. Cell growth was examined after a 3-day culture, which was preceded by exposure of the cells to cisplatin in either phosphate-buffered saline solution or distilled water for 1/2 to 5… CONTINUE READING
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