Hypothyroidism related to tyrosine kinase inhibitors: an emerging toxic effect of targeted therapy

Abstract

Despite their inherent selectivity, targeted therapies such as tyrosine kinase inhibitors (TKIs) can cause unusual adverse effects. Sunitinib and sorafenib are multitargeted TKIs that have been demonstrated to induce hypothyroidism and thyroid dysfunction. Retrospective studies indicate that sunitinib can induce hypothyroidism in 53–85% of patients, and in… (More)
DOI: 10.1038/nrclinonc.2009.4

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