Hypothyroidism Enhances Tumor Invasiveness and Metastasis Development

  title={Hypothyroidism Enhances Tumor Invasiveness and Metastasis Development},
  author={Olaia A Mart{\'i}nez-Iglesias and Susana Garc{\'i}a-Silva and Javier Regadera and Ana Aranda},
  booktitle={PloS one},
BACKGROUND Whereas there is increasing evidence that loss of expression and/or function of the thyroid hormone receptors (TRs) could result in a selective advantage for tumor development, the relationship between thyroid hormone levels and human cancer is a controversial issue. It has been reported that hypothyroidism might be a possible risk factor for liver and breast cancer in humans, but a lower incidence of breast carcinoma has been also reported in hypothyroid patients METHODOLOGY… CONTINUE READING


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