Hypothiocyanous acid reactivity with low-molecular-mass and protein thiols: absolute rate constants and assessment of biological relevance.

  title={Hypothiocyanous acid reactivity with low-molecular-mass and protein thiols: absolute rate constants and assessment of biological relevance.},
  author={Ojia Skaff and David I. Pattison and Michael Jonathan Davies},
  journal={The Biochemical journal},
  volume={422 1},
MPO (myeloperoxidase) catalyses the oxidation of chloride, bromide and thiocyanate by H(2)O(2) to HOCl (hypochlorous acid), HOBr (hypobromous acid) and HOSCN (hypothiocyanous acid, also know as cyanosulfenic acid) respectively. Specificity constants indicate that thiocyanate, SCN-, is a major substrate for MPO. HOSCN is also a major oxidant generated by other peroxidases including salivary, gastric and eosinophil peroxidases. Whereas HOCl and HOBr are powerful oxidizing agents, HOSCN appears to… 

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