Hypothetical interpretation of the calcium paradox in renin secretion


Most renin-positive cells of the preglomerular arteriole are intermediate in morphological appearence between smooth muscle cells and epithelioid cells. Intermediate cells contain, in addition to secretory granules, contractile proteins arranged as a sublemmal network. The paradoxical (inhibitory) role of calcium in renin secretion is explained, on the basis of these findings, by an increased tone of the sublemmal network; this might impair the preexocytotic access of renin granules to the cell membrane.

DOI: 10.1007/BF00216658

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@article{Taugner1988HypotheticalIO, title={Hypothetical interpretation of the calcium paradox in renin secretion}, author={Roland Taugner and Dr. R. Nobiling and Richard Metz and Felicitas M Taugner and Ch. Ph. B{\"{u}hrle and Eberhard Hackenthal}, journal={Cell and Tissue Research}, year={1988}, volume={252}, pages={687-690} }