Hypothesis testing of a change point during cognitive decline among Alzheimer's disease patients.

@article{Ji2003HypothesisTO,
  title={Hypothesis testing of a change point during cognitive decline among Alzheimer's disease patients.},
  author={Ming Ji and Chengjie Xiong and Michael Grundman},
  journal={Journal of Alzheimer's disease : JAD},
  year={2003},
  volume={5 5},
  pages={375-82}
}
In this paper, we present a statistical hypothesis test for detecting a change point over the course of cognitive decline among Alzheimer's disease patients. The model under the null hypothesis assumes a constant rate of cognitive decline over time and the model under the alternative hypothesis is a general bilinear model with an unknown change point. When the change point is unknown, however, the null distribution of the test statistics is not analytically tractable and has to be simulated by… CONTINUE READING