Hypothesis test of mediation effect in causal mediation model with high-dimensional continuous mediators.

@article{Huang2016HypothesisTO,
  title={Hypothesis test of mediation effect in causal mediation model with high-dimensional continuous mediators.},
  author={Yen-Tsung Huang and Wen-Chi Pan},
  journal={Biometrics},
  year={2016},
  volume={72 2},
  pages={402-13}
}
Causal mediation modeling has become a popular approach for studying the effect of an exposure on an outcome through a mediator. However, current methods are not applicable to the setting with a large number of mediators. We propose a testing procedure for mediation effects of high-dimensional continuous mediators. We characterize the marginal mediation effect, the multivariate component-wise mediation effects, and the L2 norm of the component-wise effects, and develop a Monte-Carlo procedure… CONTINUE READING