Hypothesis: the 'metabolic memory', the new challenge of diabetes.

  title={Hypothesis: the 'metabolic memory', the new challenge of diabetes.},
  author={Michael A. Ihnat and Jessica E. Thorpe and Antonio Ceriello},
  journal={Diabetic medicine : a journal of the British Diabetic Association},
  volume={24 6},
Large randomized studies have established that early intensive glycaemic control reduces the risk of diabetic complications, both micro- and macrovascular. However, epidemiological and prospective data support a long-term influence of early metabolic control on clinical outcomes. This phenomenon has recently been defined as 'metabolic memory.' Potential mechanisms for propagating this 'memory' are the non-enzymatic glycation of cellular proteins and lipids, and an excess of cellular reactive… CONTINUE READING

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