Hypothesis: selective phosphodiesterase-5 inhibition improves outcome in preeclampsia.

  title={Hypothesis: selective phosphodiesterase-5 inhibition improves outcome in preeclampsia.},
  author={John W Downing and Ramiah Ramasubramanian and Roger F Johnson and Beth H Minzter and Ray L Paschall and H{\aa}kan W. Sundell and Barbara Engelhardt and Ruth A. Lewis},
  journal={Medical hypotheses},
  volume={63 6},
The pathogenesis of preeclampsia stems from aberrant changes at the placental interface. The trophoblastic endovascular invasion of tonic spiral arteries that converts them to passive conduits falters. Uteroplacental insufficiency and fetoplacental hypoxemia result. Secondary maternal oxidative stress and an excessive inflammatory response to pregnancy generate the clinical syndrome of preeclampsia. Current treatment focuses on preventing seizures, controlling hypertension, preserving renal… CONTINUE READING


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