Hypothesis: one rate-limiting step controls the magnitude of both phases of glucose-stimulated insulin secretion.

Abstract

The biphasic secretory response of pancreatic beta-cells to abrupt and sustained exposure to glucose is well documented. Some of the ATP-sensitive K(+) (K(ATP)) channel-dependent mechanisms underlying the first phase of insulin release are known; the mechanisms underlying the second phase are less well known. The hypothesis we propose is that one rate… (More)

Topics

5 Figures and Tables

Cite this paper

@article{Straub2004HypothesisOR, title={Hypothesis: one rate-limiting step controls the magnitude of both phases of glucose-stimulated insulin secretion.}, author={Susanne G. Straub and Geoffrey W. G. Sharp}, journal={American journal of physiology. Cell physiology}, year={2004}, volume={287 3}, pages={C565-71} }