Hypothesis: hypersensitive plasmid copy number control for ColE1.

  title={Hypothesis: hypersensitive plasmid copy number control for ColE1.},
  author={M{\aa}ns Ehrenberg},
  journal={Biophysical journal},
  volume={70 1},
Initiation of replication of the plasmid ColE1 is primed by the cis-acting RNA II. Copy numbers are regulated by inhibition of RNA II by the antisense RNA I, whose concentration is proportional to the plasmid concentration. This inhibition is enhanced by a protein. Rom, and takes place during a time set by the transcription of 250 bases of the gene for RNA II. When this transcription is dominated by several steps of about equal duration, the probability for RNA II to prime DNA replication is… CONTINUE READING
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