Hypothesis: changes in the O2 dissociation curve and sickling: a general formulation and therapeutic strategy.


T HE RELATIONSHIP between oxygen tension and the sickling phenomenon has been recognized for over 45 years’ and has become central to our thinking about sickle cell disease. It has been emphasized that sickling of red cells depends to a large degree upon the absolute concentration of reduced sickle hemoglobin.2 In the past two decades many therapeutic… (More)

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