Corpus ID: 6198737

Hypothesis: a Y-chromosomal gene causes gonadoblastoma in dysgenetic gonads.

@article{Page1987HypothesisAY,
  title={Hypothesis: a Y-chromosomal gene causes gonadoblastoma in dysgenetic gonads.},
  author={David C. Page},
  journal={Development},
  year={1987},
  volume={101 Suppl},
  pages={
          151-5
        }
}
  • D. Page
  • Published 1 March 1987
  • Biology, Medicine
  • Development
The role of the human Y chromosome in the etiology of gonadoblastoma, a gonadal neoplasm, is considered and a two-part model is presented. According to this hypothesis: (1) There is a gene on the Y chromosome that strongly predisposes dysgenetic gonads to develop gonadoblastomas (Page, 1986) and (2) this postulated GBY gene (GonadoBlastoma locus on Y chromosome) has some physiological function in normal males. GBY may, for example, function in or prior to spermatogenesis in normal testes. Y-DNA… Expand
Molecular mapping of the putative gonadoblastoma locus on the Y chromosome
TLDR
The findings confirm the previous localization of GBY and greatly refine it, and overlaps with the region to which a putative growth determinant, GCY, was recently assigned. Expand
Gonadoblastoma: molecular definition of the susceptibility region on the Y chromosome.
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Although the results do not directly implicate TSPY or YRRM in the etiology of the tumor, they raise the issue of whether there is one GBY gene in the critical region or possibly multiple GBY loci dispersed on the Y chromosome. Expand
Risk of gonadoblastoma in female patients with Y chromosome abnormalities and dysgenetic gonads
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Early gonadectomy is recommended in female children presenting with gonadal dysgenesis and the presence of a Y chromosome although once the gonadoblastoma locus on Y chromosome gene has been cloned it may be possible to identify those patients who have a low risk of developing gonadOBlastoma. Expand
XY gonadal dysgenesis and gonadoblastoma: a study in two sisters with a cryptic deletion of the Y chromosome involving the SRY gene
TLDR
Cytogenetic studies and PCR analyses revealed absence of the conserved portion (HMG box) of the SRY gene and of the Y chromosome pseudoautosomal boundary region sequence in both patients, and the presence of the ZFY sequence was detected by Southern hybridization in the two affected sisters. Expand
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The risk of developing any kind of gonadal lesion, whether tumoral or not, justifies investigation of Y-chromosome sequences by means of the polymerase chain reaction (PCR), a highly sensitive, low-cost and easy-to-perform technique. Expand
Expression pattern of a gonadoblastoma candidate gene suggests a role of the Y chromosome in prostate cancer
TLDR
Sequence analysis of RT-PCR products obtained from both prostatic and testicular tissues revealed a complex pattern of RNA processing of the TSPY transcripts involving cryptic intron splicing and/or intron skipping, which suggests that the T SPY gene may also be involved in the multi-step prostatic oncogenesis besides its putative role in gonadoblastoma andtesticular seminoma. Expand
SRY Gene Increases the Risk of Developing Gonadoblastoma and/or Nontumoral Gonadal Lesions in Turner Syndrome
TLDR
A systematic search for hidden Y-chromosome mosaicism, especially SRY, in Turner syndrome patients is justified by the possibility of preventing gonadal lesions. Expand
The chromosome Y-linked testis-specific protein locus TSPY1 is characteristically present in gonadoblastoma.
TLDR
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SRY mutation and tumor formation on the gonads of XP pure gonadal dysgenesis patients.
TLDR
The results suggest that SRY may play a role in the formation of gonadal tumors, especially dysgerminoma, as reported in three patients with XY pure gonadal dysgenesis. Expand
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