Hypothesis: Progesterone primes breast cancer cells for cross-talk with proliferative or antiproliferative signals.

@article{Lange1999HypothesisPP,
  title={Hypothesis: Progesterone primes breast cancer cells for cross-talk with proliferative or antiproliferative signals.},
  author={Carol A. Lange and Jennifer K Richer and Kathryn B. Horwitz},
  journal={Molecular endocrinology},
  year={1999},
  volume={13 6},
  pages={829-36}
}
In the breast, data from numerous laboratories suggest that cross-talk exists between PR and growth factor and cytokine signaling pathways at multiple levels (Fig. 4). At the cell surface (level 1), progestins up-regulate growth factor and cytokine receptors. We have expanded this observation by examining the effects of progestins in the cytoplasm (level 2) where progestins regulate several intracellular effectors by increasing the levels and altering the subcellular compartmentalization of… CONTINUE READING
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