Hypothesis: Iodine, selenium and the development of breast cancer

@article{Cann2004HypothesisIS,
  title={Hypothesis: Iodine, selenium and the development of breast cancer},
  author={Stephen A. Hoption Cann and Johannes Pieter van Netten and Christiaan van Netten},
  journal={Cancer Causes \& Control},
  year={2004},
  volume={11},
  pages={121-127}
}
AbstractBackground: In this paper we examine some of the evidence linking iodine and selenium to breast cancer development. Seaweed is a popular dietary component in Japan and a rich source of both of these essential elements. We hypothesize that this dietary preference may be associated with the low incidence of benign and malignant breast disease in Japanese women. In animal and human studies, iodine administration has been shown to cause regression of both iodine-deficient goiter and benign… 
Role of iodine in antioxidant defence in thyroid and breast disease
  • P. Smyth
  • Chemistry, Medicine
    BioFactors
  • 2003
TLDR
The role played in thyroid hormonogenesis by iodide oxidation to iodine (organification) is well established and less compelling evidence exists of a role for iodide as an antioxidant in the breast.
Is Iodine A Gatekeeper of the Integrity of the Mammary Gland?
TLDR
It is proposed that an I2 supplement should be considered as an adjuvant in breast cancer therapy because of its suppressive effect on the development and size of both benign and cancer neoplasias.
The Mechanistic Role of Iodine in Breast Carcinogenesis
TLDR
Using transgenic human breast cancer cells overexpressing the sodium/iodide symporter (NIS) and/or lactoperoxidase (LPO) it is shown that NIS facilitates death or survival pathways following irradiation, a known human breast carcinogen, depending on the presence or absence of iodine.
Commentary The thyroid, iodine and breast cancer
TLDR
It remains to be resolved whether the perceived breast cancer–thyroid disease relationship is thyroid or iodine related or, in the case of thyroid autoantibodies, is the consequence of an immune response to the carcinoma.
Hypothesis: Dietary Iodine Intake in the Etiology of Cardiovascular Disease
This paper reviews evidence suggesting that iodine deficiency can have deleterious effects on the cardiovascular system, and correspondingly, that a higher iodine intake may benefit cardiovascular
The thyroid, iodine and breast cancer
  • P. Smyth
  • Medicine
    Breast Cancer Research
  • 2003
TLDR
It remains to be resolved whether the perceived breast cancer–thyroid disease relationship is thyroid or iodine related or, in the case of thyroid autoantibodies, is the consequence of an immune response to the carcinoma.
Recent Advances in Iodine Nutrition
Iodine supports the health of many organs in the body. It is taken up by most every gland and, when taken in milligram quantities, is found in nearly every tissue of the body. The thyroid cannot
The extrathyronine actions of iodine as antioxidant, apoptotic, and differentiation factor in various tissues.
TLDR
Evidence showing that, in addition to being a component of the thyroid hormone, iodine can be an antioxidant as well as an antiproliferative and differentiation agent that helps to maintain the integrity of several organs with the ability to take up iodine is reviewed.
Is Iodine an Antioxidant and Antiproliferative Agent for theMammary and Prostate Glands
This chapter reviews the evidence showing iodine to be an antioxidant and antiproliferative agent that may contribute to the integrity of normal mammary and prostate glands. Mammary and prostate
Serum Iodine and Breast Cancer Risk: A Prospective Nested Case–Control Study Stratified for Selenium Levels
TLDR
The combination of high serum iodine levels and high selenium levels was associated with a lower risk of breast cancer, suggesting a high iodine and seenium exposure may decrease the risk of Breast cancer.
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