Hypothesis: Huntingtin may function in membrane association and vesicular trafficking.

@article{Truant2006HypothesisHM,
  title={Hypothesis: Huntingtin may function in membrane association and vesicular trafficking.},
  author={Ray Truant and Randy Singh Atwal and Anjee Burtnik},
  journal={Biochemistry and cell biology = Biochimie et biologie cellulaire},
  year={2006},
  volume={84 6},
  pages={912-7}
}
Huntington's disease is a progressive neurodegenerative genetic disorder that is caused by a CAG triplet-repeat expansion in the first exon of the IT15 gene. This CAG expansion results in polyglutamine expansion in the 350 kDa huntingtin protein. The exact function of huntingtin is unknown. Understanding the pathological triggers of mutant huntingtin, and distinguishing the cause of disease from downstream effects, is critical to designing therapeutic strategies and defining long- and short… CONTINUE READING