Hypotheses relating to the function of the claustrum

  title={Hypotheses relating to the function of the claustrum},
  author={John Smythies and Lawrence Edelstein and Vilayanur S. Ramachandran},
  journal={Frontiers in Integrative Neuroscience},
This paper presents a new hypothesis as to the function of the claustrum. Our basic premise is that the claustrum functions as a detector and integrator of synchrony in the axonal trains in its afferent inputs. In the first place an unexpected stimulus sets up a processed signal to the sensory cortex that initiates a focus of synchronized gamma oscillations therein. This focus may then interact with a general alerting signal conveyed from the reticular formation via cholinergic mechanisms, and… 
An Integrated Neuronal Model of Claustral Function in Timing the Synchrony Between Cortical Areas
This model describes how the functional anatomy of the claustral connections can potentially execute the sequential activation of the representations of objects that are being processed serially and proposes that cross-frequency coupling between low frequency signals from CL and higher frequency oscillations in the cortical areas will be an efficient means of CL modulating neural activity across multiple brain regions in synchrony.
Organization of the Claustrum-to-Entorhinal Cortical Connection in Mice
The results suggest that the dense claustro–MEC pathway is activated by novel context and modulates MEC function in contextual memory.
Organization of the claustrum-to-entorhinal cortical connection in mice.
Investigation of the organization and function of identified claustro-cortical projections in mice using multiple anatomical and optogenetic techniques suggests that the dense claustra-MEC pathway is activated by novel context and modulates MEC function in contextual memory.
Single neurons and networks in the claustrum integrate input from widespread cortical sources
It is shown that the claustrum is composed of excitatory and inhibitory cell types that are connected through intraclaustral excited synapses, especially between neurons with disparate projection targets.
Interhemispheric claustral circuits coordinate sensory and motor cortical areas that regulate exploratory behaviors
The results suggest that subregions within the claustrum play a critical role in coordinating the cortical areas that regulate the acquisition of modality-specific sensory information during exploration and other behaviors that require sensory attention.
Intrinsic Connectivity of the Claustrum : Gap Junctions Demonstrated by Immunohistochemistry and Electron Microscopy
The presence of gap junctions in the claustrum was investigated in this thesis with an immunohistochemical approach to localize the gap junction protein connexin 36, and it was argued that their limited occurrence in both number and location are not entirely in line with current hypotheses predicting a wide gap junction network common to the entire claustrums.
A role of the claustrum in auditory scene analysis by reflecting sensory change
Claustral neurons were however able to detect target sounds embedded in a noisy background and their responses scaled with target signal to noise ratio (SNR) and single trial responses of individual neurons suggest that these neurons detected and reflected the occurrence of a change in the auditory scene.
The claustrum is a highway not a hub : organizing principles of claustrocortical synaptic transmission
The findings in this thesis add to the understanding of CLA functional organization by suggesting that any input received by the CLA must be sufficiently strong in order to overcome FFI and for the signal to be propagated.


Neurochemically defined cell types in the claustrum of the cat
Unimodal Responses Prevail within the Multisensory Claustrum
The claustrum receives afferent inputs from multiple sensory-related brain areas, prompting speculation about a role in integrating information across sensory modalities, and the existence of distinct claustral zones comprised of unimodal neurons associated with the auditory and visual modalities is revealed.
Connections of the auditory cortex with the claustrum and the endopiriform nucleus in the cat
Rat Claustrum Coordinates But Does Not Integrate Somatosensory and Motor Cortical Information
Although the rodent claustrum is probably involved in the interhemispheric coordination of the MI and SI whisker representations, it does not receive inputs from both of these cortical regions, and should not be universally regarded as an integrator of somesthetic and motor information.
Proprio-tactile integration for kinesthetic perception: An fMRI study
The claustrum/insula region integrates conceptually related sounds and pictures
The claustrum : structural, functional, and clinical neuroscience
The Claustrum develops a unifying hypothesis about the claustrum's role in consciousness, as well as the integration of sensory information and other higher brain functions, and discusses the involvement of the claUSTrum with autism, schizophrenia, epilepsy, Alzheimer's disease, and Parkinson's disease.
The claustrum: a historical review of its anatomy, physiology, cytochemistry and functional significance.
A review of the world literature through 1986 prior to the advent of the "molecular revolution" is presented, finding that this once obscure brain structure, may serve as a model system for the study of one of the most interesting and complex brain functions-consciousness.
The functional logic of cortico-pulvinar connections.
  • S. Shipp
  • Biology
    Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 2003
This article presents a simplified, global model of the organization of cortico-pulvinar connections so as to pursue their structure-function relationships, and identifies four topographically ordered connection domains, and reconciles the coexistence of visual and cortical maps in two of them.