Hypotheses on the etiology of antineutrophil cytoplasmic autoantibody associated vasculitis: the cause is hidden, but the result is known.

@article{Wijngaarden2008HypothesesOT,
  title={Hypotheses on the etiology of antineutrophil cytoplasmic autoantibody associated vasculitis: the cause is hidden, but the result is known.},
  author={Robert A F de Lind van Wijngaarden and Leendert van Rijn and E. Christiaan Hagen and Richard A Watts and Gina A Gregorini and Jan Willem Cohen Tervaert and Alfred Mahr and John L. Niles and Emile de Heer and Jan Anthonie Bruijn and Ingeborg M. Bajema},
  journal={Clinical journal of the American Society of Nephrology : CJASN},
  year={2008},
  volume={3 1},
  pages={237-52}
}
The first description of what is now known as antineutrophil cytoplasmic autoantibody-associated necrotizing vasculitis appeared more than 140 yr ago. Since then, many aspects of the pathogenic pathway have been elucidated, indicating the involvement of antineutrophil cytoplasmic autoantibodies, but why antineutrophil cytoplasmic autoantibodies are produced in the first place remains unknown. Over the years, many hypotheses have emerged addressing the etiology of antineutrophil cytoplasmic… CONTINUE READING
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