Hypothermic responses to infection are inhibited by alpha2-adrenoceptor agonists with possible clinical implications.

  title={Hypothermic responses to infection are inhibited by alpha2-adrenoceptor agonists with possible clinical implications.},
  author={Stephen Tolchard and P. A. Burns and David J. Nutt and Stephen M Fitzjohn},
  journal={British journal of anaesthesia},
  volume={103 4},
BACKGROUND alpha(2)-Adrenoceptor agonists are currently used as primary sedative agents in high dependency patients who are at high risk of sepsis. Clinical surveillance of such patients relies in part on their ability to mount appropriate responses to infection, in particular thermal responses. Thermoregulatory responses to infection are well studied in the rat and in this species, and humans, infection can induce febrile, hypothermic, or mixed hypothermic and febrile responses. The… 

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