Hypothermic responses to infection are inhibited by alpha2-adrenoceptor agonists with possible clinical implications.
@article{Tolchard2009HypothermicRT, title={Hypothermic responses to infection are inhibited by alpha2-adrenoceptor agonists with possible clinical implications.}, author={Stephen Tolchard and P. A. Burns and David J. Nutt and Stephen M Fitzjohn}, journal={British journal of anaesthesia}, year={2009}, volume={103 4}, pages={ 554-60 } }
BACKGROUND
alpha(2)-Adrenoceptor agonists are currently used as primary sedative agents in high dependency patients who are at high risk of sepsis. Clinical surveillance of such patients relies in part on their ability to mount appropriate responses to infection, in particular thermal responses. Thermoregulatory responses to infection are well studied in the rat and in this species, and humans, infection can induce febrile, hypothermic, or mixed hypothermic and febrile responses. The…
8 Citations
Effects of endotoxemia on the pharmacodynamics and pharmacokinetics of ketamine and xylazine anesthesia in Sprague-Dawley rats.
- Medicine, BiologyVeterinary medicine
- 2012
During ketamine-xylazine anesthesia, endotoxemia may alter xylazine pharmacokinetics and selected biochemical and physiological parameters, suggesting that anesthetic drug dosages could be modified for a more rapid recovery.
Temperament influences endotoxin-induced changes in rectal temperature, sickness behavior, and plasma epinephrine concentrations in bulls
- MedicineInnate immunity
- 2011
It is demonstrated that the temperament of calves can modulate the physiological, behavioral, and endocrine responses of pre-pubertal Brahman bulls to endotoxin challenge.
Leptin fails to blunt the lipopolysaccharide-induced activation of the hypothalamic–pituitary–adrenal axis in rats
- Biology, MedicineThe Journal of endocrinology
- 2014
The findings suggest that leptin does not influence HPA function or IL1β secretion in a rat model of LPS-induced sepsis, and thus that leptin is unlikely to be involved in the acute-phase endocrine response to bacterial infection in rats.
Enhancement of the acute phase response to a lipopolysaccharide challenge in steers supplemented with chromium
- MedicineInnate immunity
- 2012
It is suggested that chromium supplementation enhances the acute phase response of steers to an LPS challenge, which may expedite recovery.
The Relationship Amongst Stress, Temperament, and Immune Function in Brahman Cattle
- Biology
- 2011
The relationship Amongst Stress, Temperament, and Immune Function in Brahman Cattle is studied to determine the influence of temperament on stress hormones and the immune system in response to various stressors.
Fever Associated With Dexmedetomidine in Adult Acute Care Patients: A Systematic Review of the Literature
- MedicineJournal of clinical pharmacology
- 2021
Clinicians should keep dexmedetomidine‐associated fever in their differential, and stewardship programs should consider assessing for this adverse effect in their patient monitoring.
References
SHOWING 1-10 OF 54 REFERENCES
Antipyresis as a result of alpha-1 adrenoceptor blockade.
- Medicine, BiologyGeneral pharmacology
- 1993
Role of intrapreoptic norepinephrine in endotoxin-induced fever in guinea pigs.
- Biology, MedicineThe American journal of physiology
- 1993
Results suggest that intrapreoptic NE may have a thermolytic effect on fever by reducing metabolic heat production and may thus play a physiological role in the initiation of febrilysis in guinea pigs.
Hypothermia to endotoxin involves reduced thermogenesis, macrophage-dependent mechanisms, and prostaglandins.
- Biology, MedicineThe American journal of physiology
- 1994
The observation of the induction of the pyrogen interleukin-1 in the brain during the time course of the febrile response to LPS supports the hypothesis that the second phase of biphasic fever is mediated by synthesis and action of pyrogens inside the blood-brain barrier.
Comparison between thermoregulatory effects mediated by alpha 1- and alpha 2-adrenoceptors in normothermic and febrile rabbits.
- BiologyGeneral pharmacology
- 1993
Results indicate that alpha 1- and alpha 2-adrenoceptor drugs' thermoregulatory actions are similar in event and suggest that both subtypes of alpha-adRenoceptor might be implicated functionally in a variety of thermoreGulatory processes.
Role of α2A‐adrenoceptors in the effects of MDMA on body temperature in the mouse
- BiologyBritish journal of pharmacology
- 2005
The α2A‐adrenoceptor agonist actions of MDMA contribute to its effects on body temperature, but in a surprising way, and alter the body temperature response to MDMA from biphasic (hypothermia followed by hyperthermia) to monophasic hyperthemia.
Do Cardiovascular Mechanisms Participate in Thermoregulatory Activity of α2‐Adrenoceptor Agonists and Antagonists in Rabbits? a
- Biology
- 1997
This study investigated the effects of a,-adrenoceptor agonists and antagonists on the thermoregulatory functions of normothermic, febrile and cold-stressed rabbits and attempted to determine whether the changes in core body temperature induced by a,adrenOceptor compounds correlated to those in the cardiovascular system.
Comparison of the effect of prazosin with that of dihydrobenzperidol and nifidepine on thermoregulatory responses produced by pyrogen in rabbits.
- Biology, MedicineGeneral pharmacology
- 1990
Hypothermia: Role of α
1- and α
2-noradrenergic receptors in the hypothalamus of the cat
- Biology, PsychologyPharmacology Biochemistry and Behavior
- 1987
Alpha-adrenergic stimulation of corticotropin secretion by a specific central mechanism in man.
- Biology, MedicineNeuroendocrinology
- 1987
The effect of methoxamine, which is more lipid soluble than NE, on plasma ACTH and cortisol, appears to be exerted on the CNS and not at the pituitary or via nonspecific peripheral mechanisms.