Hypothermic effects of N-n-propylnorapomorphine in mice: Antagonism by neurotransmitter receptor blockers

@article{Wilcox1980HypothermicEO,
  title={Hypothermic effects of N-n-propylnorapomorphine in mice: Antagonism by neurotransmitter receptor blockers},
  author={R. E. Wilcox and William H. Riffee and Robert Vanderhoof Smith},
  journal={Psychopharmacology},
  year={1980},
  volume={68},
  pages={85-88}
}
Six receptor blockers were compared in mice for their ability to alter hypothermia induced by the dopamine agonist N-n-propylnorapomorphine (NPA). The dopamine antagonist haloperidol inhibited NPA-induced hypothermia whereas phentolamine, propranolol, sotalol, atropine, cyproheptadine, or naloxone (alpha-adrenergic, beta-adrenergic, muscarinic cholinergic, serotonergic, and opiate antagonists, respectively) failed to inhibit it. The degree of antagonism of the hypothermic effect of NPA induced… CONTINUE READING
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