Hypothermic and toxic actions of 2-butyne-1, 4-diol and other related diols in the rat.

@article{Taberner1974HypothermicAT,
  title={Hypothermic and toxic actions of 2-butyne-1, 4-diol and other related diols in the rat.},
  author={Peter V. Taberner and Melvin Pearce},
  journal={The Journal of pharmacy and pharmacology},
  year={1974},
  volume={26 8},
  pages={
          597-604
        }
}
The effects of 2-butyne-1,4-diol (BYDL) and related congeners on the body temperature of the rat have been determined. BYDL, at doses above 0·4 mmol kg−1 intraperitoneally, produced a significant fall in body temperature which was dose dependent. 2-butene-1,4-diol (BEDL) had no hypothermic action, and butane-1,4-diol (BDL) produced only a moderate fall in temperature (1·9°) which correlated with the time course of the hypnotic effect of the drug. γ-Butyrolac-tone (GBL), γ-hydroxybutyric acid… CONTINUE READING
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Neue Untersuchungen mit Gamma-Hydroxibuttersäure

  • Anaesthesiologie und Intensivmedizin/Anaesthesiology and Intensive Care Medicine
  • 1978
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