Hypothermic, initially oxygen-free, controlled limb reperfusion for acute limb ischemia.

BACKGROUND Controlled limb reperfusion has been shown to prevent the deleterious effects of ischemia-reperfusion (IR) syndrome following revascularization of acute limb ischemia (ALI). To reduce the production of cell-toxic oxygen-free radicals, we have established a new initially oxygen-free, hypothermic, heparin-coated perfusion and hemofiltration system… CONTINUE READING