Hypothermia therapy after traumatic brain injury in children.
@article{Hutchison2008HypothermiaTA, title={Hypothermia therapy after traumatic brain injury in children.}, author={J. Hutchison and R. Ward and J. Lacroix and P. Hébert and M. Barnes and D. Bohn and P. Dirks and S. Doucette and D. Fergusson and R. Gottesman and A. Joffe and H. Kirpalani and P. Meyer and K. Morris and D. Moher and R. Singh and P. Skippen}, journal={The New England journal of medicine}, year={2008}, volume={358 23}, pages={ 2447-56 } }
BACKGROUND
Hypothermia therapy improves survival and the neurologic outcome in animal models of traumatic brain injury. However, the effect of hypothermia therapy on the neurologic outcome and mortality among children who have severe traumatic brain injury is unknown.
METHODS
In a multicenter, international trial, we randomly assigned children with severe traumatic brain injury to either hypothermia therapy (32.5 degrees C for 24 hours) initiated within 8 hours after injury or to normothermia… CONTINUE READING
Paper Mentions
Blog Post
428 Citations
Therapeutic Hypothermia in Children and Adults with Severe Traumatic Brain Injury.
- Medicine
- Therapeutic hypothermia and temperature management
- 2014
- 40
- Highly Influenced
- PDF
Protective effect of moderate hypothermia on severe traumatic brain injury in children.
- Medicine
- 2009
- 17
Hypothermia for Intracranial Hypertension after Traumatic Brain Injury.
- Medicine
- The New England journal of medicine
- 2015
- 167
- PDF
Hypothermia for Traumatic Brain Injury in Children—A Phase II Randomized Controlled Trial*
- Medicine
- Critical care medicine
- 2015
- 29
- PDF
Hypothermia not Supported as a Therapeutic Option for Traumatic Brain Injury in Recent Randomized Trial.
- Medicine
- World neurosurgery
- 2016
- 2
Effect of Early Sustained Prophylactic Hypothermia on Neurologic Outcomes Among Patients With Severe Traumatic Brain Injury: The POLAR Randomized Clinical Trial
- Medicine
- JAMA
- 2018
- 68
- PDF
Therapeutic hypothermia in patients with coagulopathy following severe traumatic brain injury
- Medicine
- Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
- 2017
- 6
A review of clinical trials of hypothermia treatment for severe traumatic brain injury.
- Medicine
- Therapeutic hypothermia and temperature management
- 2011
- 5
References
SHOWING 1-10 OF 47 REFERENCES
Treatment of traumatic brain injury with moderate hypothermia.
- Medicine
- The New England journal of medicine
- 1997
- 325
Lack of effect of induction of hypothermia after acute brain injury.
- Medicine
- The New England journal of medicine
- 2001
- 1,283
- PDF
Treatment of acute traumatic brain injury in children with moderate hypothermia improves intracranial hypertension
- Medicine
- Critical care medicine
- 2002
- 123
Phase II Clinical Trial of Moderate Hypothermia after Severe Traumatic Brain Injury in Children
- Medicine
- Neurosurgery
- 2005
- 289
Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy.
- Medicine
- The New England journal of medicine
- 2005
- 667
- PDF
Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia.
- Medicine
- The New England journal of medicine
- 2002
- 2,990
- PDF